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About
the Neuroautonomic Laboratory
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Work in the Neuroautonomic Laboratory is currently focused on research involving
the neural control of the heart and autonomic cardiovascular
regulation. Present efforts are especially focused on both
clinical research and on advanced technology development
in the field of computerized electrocardiography (ECG). There
is evidence to suggest that long-duration spaceflight may
be associated with an increased propensity for ventricular
arrhythmia, mediated in part by changes in the central autonomic
nervous system. Episodes of myocardial ischemia during long-duration
space flight are also of potential concern, and improved
methods for prediction and early  detection of both arrhythmia
and ischemia are desired. The Neuroautonomic Laboratory has
recently developed or enabled several advanced ECG-based
algorithms in software that may predict both arrhythmia and
myocardial ischemia in advance of conventional ECG-based
techniques. A key aspect of these algorithms is that they
also function in real-time, rather than just offline, and so provide clinicians, including space medical clinicians, with
enhanced real-time monitoring capabilities. The algorithms
utilize techniques such as dynamic signal averaging (e.g.,
real-time multichannel high frequency QRS ECG) and advanced
real-time, beat-to-beat QT, PR, and RR interval variability
analyses.
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