Campaign
3B
Campaign 3B began in the summer of 2005 and continued
the collection of Standard Measures data, control data
for the investigators proposing potential countermeasures
and the continued evaluation of ultrasonic bone stimulation
to minimize orthostatic intolerance. The campaign was
conducted under standard conditions with controlled diet
and began with an 11- to 13-day ambulatory phase immediately
followed by a 90-day period of strict 6-degree
head-down tilt and a 14-day period of post bed
rest reconditioning and testing. The subject complement
for this campaign was 3 male subjects and 1 female subject.
A description of the investigator studies can be found
under Campaign 3A.
Maintenance of Skeletal Muscle
Mass and Function During Bed Rest.
PI: Arny A. Ferrando, PhD, Professor, Department of
Surgery, University of Texas Medical Branch, Galveston,
Texas
Gender Differences in Bed Rest:
Autonomic and Neuroendocrine Changes and Vascular Responses
in Lower and Upper Extremities.
PI: Jan Meck, PhD, NASA Johnson Space Center, Houston,
Texas
Human Cerebral Cortex Plasticity
in Response to Long-term Bedrest as an Analog to
Microgravity.
PI: Donna R. Roberts, MD, Neuroradiology Section, Department
of Radiology, University of California at San Francisco,
San Francisco, California 94143-0628
Retention of Skeletal, Musculature
and Postural Status with a Non-Invasive, Extremely
Low-Level Mechanical Signal: A Ground-Based
Evaluation of Efficacy.
PI: Clinton T. Rubin, PhD, Department of Biomedical
Engineering, State University of New York, Stony Brook,
New York 11794-2580
Effect of Ultrasonic Bone Conductance
on Orthostatic Tolerance During Bed Rest.
PI: Chester A. Ray, PhD, Professor of Medicine and Cellular
and Molecular Physiology, Department of Medicine, Division
of Cardiology, The Pennsylvania State College of Medicine,
Hershey, Pennsylvania
Campaign 3B was the third in a series of investigations
to use the multi-discipline approach to study the
effects of microgravity in a ground-based model.
Campaign 3B represented the control group of subjects
for these investigations and also provided the opportunity
to evaluate whether ultrasonic bone stimulation of the
mastoid improved orthostatic tolerance. An additional
investigation researched the mechanisms of the effects
of bed rest on the cardiovascular system and explored
potential gender differences in the response of the
cardiovascular system. The Standard Measures protocols
were performed together with these investigator studies
during this campaign.
Due to the threat from Hurricane Rita, the subjects
were released from the study and evacuated from the
GCRC, and the campaign ended. Subjects in this campaign
completed from 44 to 53 days of 6-degree head-down
tilt. Post bed rest data collection was limited to 1
day and was prioritized for maximum science return.
Sample and data analysis are continuing. At this time
it is unknown what effect the abbreviated campaign will
have on the scientific results and conclusions. It is
hoped that the results from Campaign 3B will be combined
with the results from the previously completed campaigns.
Data from these bed rest campaigns will serve as control
data for the assessment and evaluation of the countermeasures
proposed by the investigators.
<
Previous | Continue
>
|
