Note:
These are the general screening criteria. Certain campaigns
may invoke additional screening criteria.
Subject Recruitment Criteria
Subjects will be healthy adults, aged 25 to 55 years.
Both males and females will be recruited with the specific
requirement that a sufficient number of female subjects
are recruited to allow potential gender-specific differences
in bed rest responses to be statistically analyzed.
Subjects will be excluded from the study who:
- Require medication that may interfere with the interpretation of the results
- Have a recent sub-standard nutritional status
- Have a history of thyroid dysfunction, renal stones, mental illness, or smoking within 6 months prior to the start of the study
- Have a family history of thrombosis
- Are using hormonal contraceptives
- Are menopausal
- Cannot clear a criminal background check
- Currently on bisphosphonate therapy
- Have a positive pregnancy test (females)
- Have a history of gastroesophageal reflux disease
Potential subjects also will be screened to match the following physiologic characteristics
to those of the U.S. astronaut corps. Subjects will be
required to pass a modified Air Force Class III Physical
examination, or equivalent, within 1 year before the study
starts, and each must be capable of giving informed consent.
The tests to be performed include: vital signs, 12-lead
ECG, vision and audiometry, urine analysis, full physical
exam, electrolyte panel, complete blood count with differential,
test of liver function, drug screen, TB skin test, lipid
panel, chest X-ray, HIV/hepatitis screen, and high
sensitivity C-reactive protein. All subjects will be tested
and interviewed by a psychologist to ensure they have
the mental fitness necessary to complete all aspects of
the bed rest studies. In addition to these criteria, individual
investigators also have additional subject selection recruitment
criteria.
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