Volume 156, Number 5, Part 2, November 2001
Models for Evaluation of Radiation Risk Factors

PREFACE (p. 571)

INITIAL RESPONSE TO IONZING RADIATION
K. M. Prise, M. Pinto, H. C. Newman and B. D. Michael
A Review of Studies of Ionizing Radiation-Induced Double-Strand Break Clustering (p. 572) [abstract]

H. Nikjoo, P. O'Neill, W. E. Wilson and D. T. Goodhead
Computational Approach for Determining the Spectrum of DNA Damage Induced by Ionizing Radiation (p. 577) [abstract]

M. Weinfeld, A. Rasouli-Nia, M. A. Chaudhry and R. A. Britten
Response of Base Excision Repair Enzymes to Complex DNA Lesions (p. 584) [abstract]

T. J. Jenner, J. Fulford and P. O'Neill
Contribution of Base Lesions to Radiation-Induced Clustered DNA Damage: Implication for Models of Radiation Response (p. 590) [abstract]

A. L. Ponomarev, F. A. Cucinotta, R. K. Sachs, D. J. Brenner and L. E. Peterson
Extrapolation of the DNA Fragment-Size Distribution after High-Dose Irradiation to Predict Effects at Low Doses (p. 594) [abstract]

CELLULAR AND MOLECULAR BIOLOGY MODELS OF RADIATION RESPONSES
T. Kawata, M. Durante, Y. Furusawa, K. George, H. Ito, H. Wu and F. A. Cucinotta
Rejoining of Isochromatid Breaks Induced by Heavy Ions in G2-Phase Normal Human Fibroblasts (p. 598) [abstract]

Honglu Wu
Probabilities of Radiation-Induced Interchromosomal and Intrachromosomal Exchanges and their Dependence on the DNA Content of the Chromosome (p. 603) [abstract]

J. Kiefer, P. Schmidt and S. Koch
Mutations in Mammalian Cells Induced by Heavy Charged Particles: An Indicator for Risk Assessment in Space (p. 607) [abstract]

D. J. Brenner and C. D. Elliston
The Potential Impact of Bystander Effects on Radiation Risks in a Mars Mission (p. 612) [abstract]

Mary Helen Barcellos-Hoff and Antone L. Brooks
Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects and Genomic Instability (p. 618) [abstract]

Bruce A. Carnes and Natalia Gavrilova
Risk Analysis: Divergent Models and Convergent Interpretations (p. 628) [abstract]

Bryn A. Bridges
Radiation and Germline Mutation at Repeat Sequences: Are We in the Middle of a Paradigm Shift? (p. 631) [abstract]

Tej K. Pandita
The Role of ATM in Telomere Structure and Function (p. 642) [abstract]

K. Sankaranarayanan and R. Chakraborty
Impact of Cancer Predisposition and Radiosensitivity on the Population Risk of Radiation-Induced Cancers (p. 648) [abstract]

HUMAN FUNDAMENTAL STUDIES
Sally A. Amundson, Michael Bittner, Paul Meltzer, Jeffrey Trent and Albert J. Fornace, Jr.
Induction of Gene Expression as a Monitor of Exposure to Ionizing Radiation (p. 657) [abstract]

M. Durante, S. Bonassi, K. George and F. A. Cucinotta
Risk Estimation Based on Chromosomal Aberrations Induced by Radiation (p. 662) [abstract]

B. N. Ford, D. Wilkinson, E. M. Thorleifson and B. L. Tracy
Gene Expression Responses in Lymphoblastoid Cells after Radiation Exposure (p. 668) [abstract]

HUMAN DATA AND INTERPRETATION
Megu Ohtaki and Ohtsura Niwa
A Mathematical Model of Radiation Carcinogenesis with Induction of Genomic Instability and Cell Death (p. 672) [abstract]

W. F. Heidenreich and H. G. Paretzke
The Two-Stage Clonal Expansion Model as an Example of a Biologically Based Model of Radiation-Induced Cancer (p. 678) [abstract]

Francis A. Cucinotta, Walter Schimmerling, John W. Wilson, Leif E. Peterson, Gautam Badhwar, Premkumar Saganti and John F. Dicello
Space Radiation Cancer Risks and Uncertainties for Mars Missions (p. 682) [abstract]

G. De Angelis, M. Caldora, M. Santaquilani, R. Scipione and A. Verdecchia
Health Risks from Radiation Exposure for Civilian Aviation Flight Personnel: A Study of Italian Airline Crew Members (p. 689) [abstract]